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Can Metizolam be Used for the Treatment of Insomnia like Etizolam

Posted by in on October 04, 2016 . .

Understanding Metizolam


Metizolam, which is also marketed as desmethyletizolam, is a psychoactive drug which belongs to the thienodiazepine class. It is closely related to etizolam but has 60% longer half-life and 50% less potent than etizolam. Metizolam has been first marketed by a Japanese company as an anti-anxiety medication, but little is known about this research chemical. However, some clinical reports suggest that metizolam can act as depressant, sedative and muscle relaxant.

Understanding Etizoalm


Etizolam, which is marketed under the brand name Etilaam, Etizola or Depas, is an analogue of benzodiazepine family. The etizolam molecule features a fused thiophene ring and triazole ring, making it a thienotriazolodiazepine compound. It possesses anticonvulsant, anxiolytic, hypnotic, sedative and skeletal muscle relaxant properties. It is used for the treatment of mild insomnia. Several researches also confirm that etizolam has specific selectivity for the Y-aminobutyric acid type A receptors, which are known to be associated with anxiety. A thienodiazepine derivative, etizolam is comparable with other short-acting benzodiazepines and produces a variety of effects by binding to the benzodiazepine receptor site. It can magnify the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. 


Metizolam contains a thiophene ring fused to a diazepine ring. Though it structurally differs from its parent compound etizolam as its triazole ring does not contain methyl group, but both has the same basic structure. That means metozolam has the similar power of affecting cognitive performance as well as help insomnia patients. To determine the exact answer, scientists and researchers must conduct experiment on metizolam for its role in sleep deprivation prevention. Research labs can buy legal high powders online at research chemical supplier website to get their high quality research chemicals – metizolam and etizolam. This will help them to understand the impact of both compounds on insomnia patients as well as determine the efficacy.