Methiopropamine can function as a selective norepinephrine-dopamine reuptake inhibitor that is roughly 1.85 times more selective for norepinephrine than dopamine. It is approximately 1/3 as potent as dextroamphetamine as a norepinephrine reuptake inhibitor and one fifth as much as a dopamine reuptake inhibitor. It displays negligible activity as a serotonin reuptake inhibitor.
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