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Pentedrone legal herbal high: Affects dopaminergic activity

Posted by in on September 05, 2016 . .


  • Scientific Name:  2-(methylamino)-1-phenylpentan-1-one
  • Classification:  Stimulant
  • Effects:  Like other cathinones, pentedrone produces increased energy, focus, alertness and euphoria.  Its effects are intense and short-lived.

Pentedrone is a legal herbal high also known as 2--1-phenylpentan-1-one or α-methylamino-valerophenone which has been available since 2010 as an ingredient in a number of "bath salt" mixes sold as legal highs.

Pentedrone produces psychosttuimulant effects

Cathinone derivatives are new synthetic drugs known to produce psychostimulant effects. In a study titled “The new stimulant designer compound pentedrone exhibits rewarding properties and affects dopaminergic activit,” researchers investigated the effects of pentedrone, a type of cathinone derivative, on the dopaminergic system using reverse transcription polymerase chain reaction and Western blot. They found that pentedrone increases the mRNA expression of dopamine 1 receptor, dopamine 2 receptor and dopamine transporter, as well as induced phosphorylation of cAMP response element-binding protein in PC-12 cells.

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Pentedrone also increases the conditioned place preference in mice and self-administration in rats while acute administration of pentedrone enhanced locomotor activity in a dose-dependent manner. In short, pentedrone has rewarding effects on the dopaminergic system. 

Effects of pentedrone

Pentedrone acts as a norepinephrine-dopamine reuptake inhibitor without causing their release, the same mechanism of action as methylphenidate. Pentedrone also produces discriminative stimulus effects similar to those of cocaine and methamphetamine.

Unlike other psychostimulants, the addictive potential of cathinone derivatives has not been widely studied. So, scientists can buy legal herbal highs such as pentedrone in online research chemical store and study more about the dopaminergic effects of it. This product is sold only for research uses in laboratory settings. Researchers who work with it are advised to wear the appropriate safety gear and follow standard safety protocols while handling it.